An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas
作者: Aurelia NoskeMichael SchwabeWilko WeichertSilvia Darb-EsfahaniAnn-Christin BuckendahlJalid SehouliElena I BraicuJan BudcziesManfred DietelCarsten Denkert
作者单位: 1University Hospital Charité Berlin
2University Hospital Zurich
刊名: BMC Cancer, 2011, Vol.11 (1)
来源数据库: Springer Journal
DOI: 10.1186/1471-2407-11-294
关键词: EGFRCRM1COX-2ovarian cancerprognosis
英文摘要: Abstract(#br) Background(#br)In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting. Methods: In this study we investigated EGFR expression and its prognostic value in a cohort of 121 invasive ovarian carcinomas, using a novel antibody against the intracellular domain of the receptor. We further evaluated an association between EGFR, the nuclear transporter CRM1 as well as COX-2. Furthermore, we evaluated EGFR expression in ten ovarian cancer cell lines and incubated cancer cells with Leptomycin B, a CRM1 specific inhibitor.(#br) Results(#br)We observed a membranous and cytoplasmic EGFR expression in 36.4% and 64% of ovarian carcinomas, respectively. Membranous EGFR was an independent...
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影响因子:3.333 (2012)

  • ovarian 卵巢的
  • targeted 对准目标的
  • antibody 抗体
  • intracellular 胞内的
  • prognostic 预测的
  • independent 独立的
  • factor 因素