Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
作者: Pavel DostalJitka SchreiberovaVlasta DostalovaVlasta DostalovaTomas TyllJiri ParalIslam AbdoMiroslav CihloDavid AstapenkoZdenek Turek
作者单位: 1Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove
2Charles University, 1st Faculty of Medicine Prague, Military University Hospital Prague
3Faculty of Military Health Sciences, Hradec Kralove, University of Defence
刊名: BMC Anesthesiology, 2015, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12871-015-0067-z
关键词: BrainHypertonic salineMannitolMicrocirculationOsmotherapy
英文摘要: Abstract(#br) Background(#br)Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model.(#br) Methods(#br)Rabbits (weight, 2.0–3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global...
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影响因子:1.188 (2012)

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关键词翻译
关键词翻译
  • rabbit 
  • saline 盐的
  • cortical 皮层的
  • craniotomy 颅骨切开术
  • mannitol 甘露糖醇
  • hypertonic 过度紧张的
  • cerebral 大脑的
  • model 模型