Three-component synthesis of pyrano[2,3- d ]pyrimidinone derivatives catalyzed by Ni<sup>2+</sup> supported on hydroxyapatite-core–shell-γ-Fe<sub>2</sub>O<sub>3</sub> nanoparticles in aqueous medium
作者: Sobhan RezayatiZahra AbbasiEshagh Rezaee NezhadRahimeh HajinasiriAbdolhadi Farrokhnia
作者单位: 1Islamic Azad University
2Shahid Chamran University
3Payame Noor University
刊名: Research on Chemical Intermediates, 2016, Vol.42 (10), pp.7597-7609
来源数据库: Springer Nature Journal
DOI: 10.1007/s11164-016-2555-2
关键词: NanoparticlesLewis acid catalystSupported Ni2+Multicomponent reactionPyrano[23- d ]pyrimidinoneKnoevenagel reaction
原始语种摘要: Abstract(#br)Pyrano[2,3- d ]pyrimidine derivatives were synthesized via one-pot, three-component condensation reaction of aromatic aldehydes, malononitrile, and barbituric acid in aqueous ethanol catalyzed by Ni2+ supported on hydroxyapatite-core–shell-γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+ NPs) as Lewis acid. The nontoxic nature and easy handling of the catalyst, environmentally friendly and facile work-up procedure, short reaction time, low catalyst loading, and high effectiveness to give products in good to excellent yield are advantages of this approach. Also, γ-Fe2O3@HAp-Ni2+ NPs can be easily recovered and reused for at least six runs.
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影响因子:0.88 (2012)

  • supported 支承的
  • catalyzed 催化的
  • derivatives 派生物
  • shell 贝壳
  • hydroxyapatite 羟磷灰石层析
  • component 成分
  • medium 介质
  • aqueous 水的
  • synthesis 合成
  • core 岩心