Contemplating 3-Hydroxypropionic Acid Biosynthesis in Klebsiella pneumoniae
作者: Ying LiPingfang Tian
作者单位: 1Beijing University of Chemical Technology
刊名: Indian Journal of Microbiology, 2015, Vol.55 (2), pp.131-139
来源数据库: Springer Journal
DOI: 10.1007/s12088-015-0513-0
关键词: 3-Hydroxypropionic acidKlebsiella pneumoniaeCofactor regenerationGenome editingLogic gateSynthetic biology
英文摘要: Abstract(#br)3-Hydroxypropionic acid (3-HP) is a commercially valuable platform chemical from which an array of C3 compounds can be generated. Klebsiella pneumoniae has been considered a promising species for biological production of 3-HP. Despite a wealth of reports related to 3-HP biosynthesis in K. pneumoniae , its commercialization is still in infancy. The major hurdle hindering 3-HP overproduction lies in the poor understanding of glycerol dissimilation in K . pneumoniae . To surmount this problem, this review aims to portray a picture of 3-HP biosynthesis, involving 3-HP-synthesizing strains, biochemical attributes, metabolic pathways and key enzymes. Inspired by the state-of-the-art advances in metabolic engineering and synthetic biology, here we advocate protocols for...
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影响因子:0.457 (2012)