Racecadotril in the management of rotavirus and non-rotavirus diarrhea in under-five children: Two randomized, double-blind, placebo-controlled trials
作者: Gagandeep KangSowmyanarayanan V. ThuppalRajan SrinivasanRajiv SarkarBeula SubashiniSrinivasan VenugopalKulandaipalayam SindhuDhivya AnbuNathalie ParezLennart SvenssonAnuradha Bose
作者单位: 1Christian Medical College
2Assistance Publique-Hôpitaux de Paris
3Linko ping University
刊名: Indian Pediatrics, 2016, Vol.53 (7), pp.595-600
来源数据库: Springer Nature Journal
DOI: 10.1007/s13312-016-0894-0
关键词: AntidiarrhealAnti-secretoryOutcomeTreatment
原始语种摘要: Abstract(#br) Objective(#br)To study the effect of racecadotril on reduction in the duration of acute rotavirus and non-rotavirus diarrhea.(#br) Design(#br)Two randomized double-blind placebo-controlled trials(#br) Setting(#br)Community-based trial in an urban area in Vellore, hospital-based trial at a secondary hospital in Vellore(#br) Participants(#br)199 and 130 3-59 month old children in the community- and hospital-based trials, respectively.(#br) Methods(#br)Racecadotril (1.5 mg/kg/dose, thrice a day for three days) or placebo were given to manage acute diarrhea in both trials.(#br) Main outcome measure(#br)Median duration of diarrhea.(#br) Results(#br)Among 124 children completing the hospital trial, the median duration of diarrhea was 25 h in both arms ( P =0.5); median total stool...
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影响因子:1.036 (2012)

  • rotavirus 轮状病毒
  • diarrhea 腹泻
  • controlled 受控
  • children 子女
  • placebo 无效对照药
  • management 管理
  • under 在下