miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells
作者: Hantao WangFuao CaoXu LiHua MiaoJifu EJunjie XingChuan-gang Fu
作者单位: 1Changhai Hospital
2The First People’s Hospital of Pinghu
刊名: BMC Cancer, 2015, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-015-1728-5
关键词: Colorectal cancer (CRC)miR-320bc-MycCyclin D1
英文摘要: Abstract(#br) Background(#br)MicroRNAs (miRNAs) are small noncoding RNAs that potentially play a critical role in tumorigenesis. Mounting evidence indicates that one specific miRNA: miR-320b is down regulated in numerous human cancers, including colorectal cancer (CRC); making the hypothesis that miR-320b may play a key role in tumorigenesis plausible. However, its role in carcinogenesis remains poorly defined. The goal of this study is to better clarify the role of miR-320b in tumor growth of CRC.(#br) Methods(#br)Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was conducted to detect the expression of miR-320b in CRC tissues and 5 CRC cell lines. The effect of miR-320b on cell proliferation was analyzed in vitro and in vivo . Furthermore, a luciferase reporter...
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影响因子:3.333 (2012)

  • targeting 导向目标
  • colorectal 结肠直肠的
  • cells 麻风细胞
  • cancer 癌症
  • proliferation 增生
  • human 人的