Genetics of ion homeostasis in Ménière’s Disease
作者: Roberto TeggiLaura ZagatoSimona Delli CarpiniLorena CitterioClaudia CassandroRoberto AlberaWen-Yi YangJan A. StaessenMario BussiPaolo ManuntaChiara Lanzani
作者单位: 1ENT Division, Department of ENT, IRCCS San Raffaele Scientific Institute
2Genomics of Renal Diseases and Hypertension Unit, Division of Genetics and Cellular Biology, IRCCS San Raffaele Scientific Institute
3Surgical Sciences Department, University of Turin
4Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven
5Chair of Nephrology, Vita-Salute San Raffaele University
刊名: European Archives of Oto-Rhino-Laryngology, 2017, Vol.274 (2), pp.757-763
来源数据库: Springer Nature Journal
DOI: 10.1007/s00405-016-4375-9
关键词: Ménière’s DiseaseGeneticsIonic transportersSalt inducible kinase 1 (SIK1)Na + -Ca ++ exchanger 1 (SLC8A1)
原始语种摘要: Abstract(#br)Aim of this work was to assess the role of polymorphisms belonging to genes involved in the regulation of ionic homeostasis in Caucasian patients with Ménière Disease (MD). We recruited 155 patients with definite Ménière Disease and 186 controls (Control Group 1) without a lifetime history of vertigo, overlapping with patients for age and rate of hypertension. We validated the positive results on 413 Caucasian subjects selected from a European general population (Control Group 2). The clinical history for migraine and hypertension was collected; genomic DNA was characterized for a panel of 33 SNPs encoding proteins involved in ionic transport. We found a higher rate of migraineurs in MD subjects compared to Group 1 (46.8 vs 15.5%, p = 0.00005). Four SNPs displayed differences...
全文获取路径: Springer Nature  (合作)
影响因子:1.458 (2012)

  • 重新 国家保险
  • ni 国家保险
  • re 国家保险
  • homeostasis 体内平衡