Cellular prostatic acid phosphatase (cPAcP) serves as a useful biomarker of histone deacetylase (HDAC) inhibitors in prostate cancer cell growth suppression
作者: Yu-Wei ChouFen-Fen LinSakthivel MuniyanFrank C LinChing-Shih ChenJue WangChao-Cheng HuangMing-Fong Lin
作者单位: 1Kaohsiung Chang Gung Memorial Hospital
2University of Nebraska Medical Center
3University of Arizona Medical Center
4The Ohio State University
5University of Arizona Cancer Center, St. Joseph’s Hospital and Medical Center
6Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine
7Kaohsiung Medical University
刊名: Cell & Bioscience, 2015, Vol.5 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13578-015-0033-y
关键词: Prostate cancerHistone deacetylase inhibitorCellular prostatic acid phosphataseBiomarker
英文摘要: Abstract(#br) Background(#br)Prostate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cancer death in the United States, and also one of the major cancer-related deaths in Chinese. Androgen deprivation therapy (ADT) is the first line treatment for metastatic PCa. PCa ultimately relapses with subsequent ADT treatment failure and becomes castrate-resistant (CR). It is important to develop effective therapies with a surrogate marker towards CR PCa.(#br) Method(#br)Histone deacetylase (HDAC) inhibitors were examined to determine their effects in androgen receptor (AR)/cellular prostatic acid phosphatase (cPAcP)-positive PCa cells, including LNCaP C-33, C-81, C4-2 and C4-2B and MDA PCa2b androgen-sensitive and androgen-independent cells, and AR/cPAcP-negative PCa...
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影响因子:3 (2012)

  • prostatic 前列腺的
  • prostate 前列腺
  • deacetylase 脱乙酰基酶
  • phosphatase 磷酸酶
  • histone 组蛋白
  • biomarker 生物标志化合物
  • useful 有用的
  • suppression 抑制
  • growth 生长
  • cancer 癌症