Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer
作者: Phillip StahlCarsten SeeschaafPatrick LebokAsad KutupMaximillian BockhornJakob R IzbickiCarsten BokemeyerRonald SimonGuido SauterAndreas H Marx
作者单位: 1University Medical Center Hamburg-Eppendorf
刊名: BMC Gastroenterology, 2015, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12876-015-0231-4
关键词: HER2EGFRMYCCCND1Gene amplificationGastric cancerHeterogeneity tissue microarray
英文摘要: Abstract(#br) Background(#br)Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic gene alterations (MYC) had not been systematically studied.(#br) Methods(#br)To study heterogeneity of these genes in a large patient cohort, a heterogeneity tissue microarray was constructed containing 0.6 mm tissue cores from 9 different areas of the primary gastric cancers of 113 patients and matched lymph node metastases from 61 of these patients. Dual color fluorescence in-situ hybridization was performed to assess amplification of HER2, EGFR, CCND1 and MYC using established thresholds (ratio ≥ 2.0). Her2 immunohistochemistry (IHC) was performed in...
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影响因子:2.11 (2012)

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关键词翻译
关键词翻译
  • amplification 放大
  • gastric 胃的
  • cancer 癌症