Proanthocyanidins polymeric tannin from Stryphnodendron adstringens are active against Candida albicans biofilms
作者: Raul Leal Faria LuizTaissa Vieira Machado VilaJoão Carlos Palazzo de MelloCelso Vataru NakamuraSonia RozentalKelly Ishida
作者单位: 1Universidade Federal do Rio de Janeiro
2Laboratório de Biologia Farmacêutica, Palafito, Departamento de Farmácia Universidade Estadual de Maringá
3Universidade Estadual de Maringá
4Universidade de São Paulo
刊名: BMC Complementary and Alternative Medicine, 2015, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12906-015-0597-4
关键词: AntifungalBiofilmCandida albicansProanthocyanidinStryphnodendron adstringensTannins
英文摘要: Abstract(#br) Background(#br)Biofilm formation is important in Candida albicans pathogenesis and constitutes a mechanism of antifungal resistance. Thus, we evaluated the effect of proanthocyanidins polymer-rich fractions from Stryphnodendron adstringens (fraction F2 and subfraction F2.4) against C. albicans biofilms.(#br) Methods(#br)Firstly, the antifungal activity of F2 and F2.4 against planktonic cells of Candida albicans (ATCC 10231) was determined using broth microdilution method. Anti-biofilm effect of F2 and F2.4 was evaluated during biofilm formation or on mature biofilm of C. albicans and compared with standard antifungals amphotericin B and fluconazole. Metabolic activity of sessile and dispersion cells from biofilms after antifungal treatments were measured using a tetrazolium...
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影响因子:2.082 (2012)

  • polymeric 聚合的
  • Candida 坎迪德
  • albicans 白的
  • against 反对
  • tannin 丹宁
  • active 活动的