Taurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis
作者: Tyson J. MacCormackN. I. CallaghanA. V. SykesW. R. Driedzic
作者单位: 1Mount Allison University
2Universidade do Algarve
3Memorial University of Newfoundland
刊名: Journal of Comparative Physiology B, 2016, Vol.186 (2), pp.215-227
来源数据库: Springer Nature Journal
DOI: 10.1007/s00360-015-0946-0
关键词: Coleoid2-Aminoethanesulfonic acidPerfused heartBranchial heartCalcium
英文摘要: Abstract(#br)Taurine is the most abundant amino acid in the blood of the cuttlefish, Sepia officinalis , where levels can exceed 200 mmol L−1. In mammals, intracellular taurine modulates cardiac Ca2+ handling and carbohydrate metabolism at much lower concentrations but it is not clear if it exerts similar actions in cephalopods. Blood Ca2+ levels are high in cephalopods and we hypothesized that taurine would depress cardiac Ca2+ flux and modulate contractility in systemic and branchial hearts of cuttlefish. Heart performance was assessed with an in situ perfused systemic heart preparation and contractility was evaluated using isometrically contracting systemic and branchial heart muscle rings. Stroke volume, cardiac output, and Ca2+...
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影响因子:2.024 (2012)

  • cuttlefish 墨鱼
  • contractility 收缩性
  • systemic 系统的
  • glucose 葡萄糖
  • cardiac 贲门
  • utilization 利用
  • heart 心脏