Histone deacetylase inhibitor sodium butyrate suppresses DNA double strand break repair induced by etoposide more effectively in MCF-7 cells than in HEK293 cells
作者: Liping LiYouxiang SunJiangqin LiuXiaodan WuLijun ChenLi MaPengfei Wu
作者单位: 1Guangdong Medical College
刊名: BMC Biochemistry, 2015, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12858-014-0030-5
关键词: Double strand breaksHistone deacetylase inhibitorMCF-7HEK293EtoposideSodium butyrate
英文摘要: Abstract(#br) Background(#br)Histone deacetylase inhibitors (HDACi’s) are emerging as promising anticancer drugs alone or in combination with chemotherapy or radiotherapy agents. Previous research suggests that HDACi’s have a high degree of selectivity for killing cancer cells, but little is known regarding the impact of different cellular contexts on HDACi treatment. It is likely that the molecular mechanisms of HDACi’s involve processes that depend on the chromatin template, such as DNA damage and repair. We sought to establish the connection between the HDACi sodium butyrate and DNA double-strand break (DSB) damage in human breast cancer MCF-7 and non-cancerous human embryonic kidney293 (HEK293) cells.(#br) Results(#br)Sodium butyrate inhibited the proliferation of both HEK293 and...
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影响因子:1.776 (2012)

  • etoposide 足叶乙甙
  • deacetylase 脱乙酰基酶
  • effectively 有效地
  • cells 麻风细胞
  • butyrate 丁酸酸盐
  • strand 海滨
  • induced 感应的
  • double 双重的
  • repair 修理
  • sodium