Predicting the response of patients with advanced urothelial cancer to methotrexate, vinblastine, Adriamycin, and cisplatin (MVAC) after the failure of gemcitabine and platinum (GP)
作者: Ki Hong KimSung Joon HongKyung Seok Han
作者单位: 1Yonsei University College of Medicine
刊名: BMC Cancer, 2015, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-015-1825-5
关键词: Urothelial carcinomaChemotherapyCisplatinSecond-line
英文摘要: Abstract(#br) Background(#br)Platinum-based systemic chemotherapy is the treatment of choice for patients with advanced urothelial carcinoma (UC). Although no chemotherapeutic regimen is established as a second-line therapy, recent studies reported that methotrexate, vinblastine, Adriamycin and cisplatin (MVAC) elicited a significant response in patients who failed gemcitabine and platinum (GP) chemotherapy. We investigated the clinical factors useful for predicting a favourable response to MVAC in UC patients who failed GP.(#br) Methods(#br)Forty-five patients with advanced UC who received second-line MVAC chemotherapy after failure with first-line GP chemotherapy were enrolled in this study. Univariate and multivariate analyses based on Cox’s regression were performed to identify...
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影响因子:3.333 (2012)

  • vinblastine 长春花碱
  • Adriamycin 阿霉素
  • GP General Poll
  • methotrexate 氨甲喋呤
  • platinum 
  • response 响应
  • cancer 癌症
  • advanced 先进的
  • failure 破坏
  • after 在之后