The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo
作者: Yuh-Feng LinI-Jen ChiuFong-Yu ChengYu-Hsuan LeeYing-Jan WangYung-Ho HsuHui-Wen Chiu
作者单位: 1Shuang Ho Hospital, Taipei Medical University
2Taipei Medical University
3National Cheng Kung University
4College of Medicine, National Cheng Kung University
5Asia University
6China Medical University Hospital, China Medical University
7School of Medicine, College of Medicine, Taipei Medical University
刊名: Particle and Fibre Toxicology, 2015, Vol.13 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12989-016-0163-3
关键词: Hypoxia-inducible factor-1αZinc oxide nanoparticlesNephrotoxicityAutophagyApoptosis
原始语种摘要: Abstract(#br) Background(#br)Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molecular mechanisms underlying ZnO NP nephrotoxicity remain unclear. In this study, we evaluated the potential toxicity of ZnO NPs in kidney cells in vitro and in vivo.(#br) Results(#br)We found that ZnO NPs were apparently engulfed by the HEK-293 human embryonic kidney cells and then induced reactive oxygen species (ROS) generation. Furthermore, exposure to ZnO NPs led to a reduction in cell viability and induction of apoptosis and autophagy. Interestingly, the ROS-induced hypoxia-inducible factor-1α (HIF-1α) signaling pathway was significantly increased...
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影响因子:9.178 (2012)

  • nephrotoxicity 中毒性肾损害
  • hypoxia 氧过少
  • induced 感应的
  • factor 因素
  • nanoparticle 乳酸
  • inducible 可归纳的
  • vitro 体外
  • oxide 氧化物