Inducible gene expression system by 3-hydroxypropionic acid
作者: Shengfang ZhouSatish Kumar AinalaEunhee SeolTrinh Thi NguyenSunghoon Park
作者单位: 1Pusan National University
2Changzhou University
刊名: Biotechnology for Biofuels, 2015, Vol.8 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13068-015-0353-5
关键词: 3-Hydroxypropionic acidLysRInduciblehpdHmmsAhbdH
英文摘要: Abstract(#br) Background(#br)3-Hydroxypropionic acid (3-HP) is an important platform chemical that boasts a variety of industrial applications. Gene expression systems inducible by 3-HP, if available, are of great utility for optimization of the pathways of 3-HP production and excretion.(#br) Results(#br)Here we report the presence of unique inducible gene expression systems in Pseudomonas denitrificans and other microorganisms. In P. denitrificans , transcription of three genes ( hpdH , mmsA and hbdH -4) involved in 3-HP degradation was upregulated by 3-HP by the action of a transcriptional regulator protein, LysR, and a cis -acting regulatory site for LysR binding. Similar inducible systems having an LysR transcriptional regulator were identified in other microorganisms that also could...
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影响因子:5.552 (2012)

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  • system