Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans
作者: Li ZhaoJinping LinHualei WangJingli XieDongzhi Wei
作者单位: 1East China University of Science and Technology
刊名: Bioprocess and Biosystems Engineering, 2015, Vol.38 (12), pp.2487-2495
来源数据库: Springer Nature Journal
DOI: 10.1007/s00449-015-1486-4
关键词: 3-Hydroxypropionic acidGlycerolKlebsiella pneumoniaeGluconobacter oxydansTwo-step process
原始语种摘要: Abstract(#br)In this work, a two-step process was developed for the production of 3-hydroxypropionic acid from glycerol. In the first step, glycerol was converted to 1,3-propanediol by Klebsiella pneumonia. In the second step, the 1,3-propanediol was converted into 3-hydroxypropionic acid by Gluconobacter oxydans . In a 7.0 L bioreactor, the whole process took 54 h, consumed 480 g glycerol and produced 242 g 3-hydroxypropionic acid. The conversion rate of glycerol to 3-hydroxypropionic acid was 50.4 % (g g−1). The final concentration of 3-hydroxypropionic acid arrived 60.5 g L−1. The process was effective for 3-HP production from glycerol and it might provide a new approach to the biosynthesis of 3-HP from a cheap starting material. Moreover, in this paper, it was...
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影响因子:1.869 (2012)

  • glycerol 甘油
  • production 生产
  • process 过程