Modulation of 17β-estradiol induced estrogenic responses in male goldfish ( Carassius auratus ) by benzo[a]pyrene and ketoconazole
作者: Zhenhua YanGuanghua LuQiuxia YeJianchao Liu
作者单位: 1Hohai University
2Jiangsu Province Communications Planning and Design Institute Co., Ltd.
刊名: Environmental Science and Pollution Research, 2016, Vol.23 (9), pp.9036-9045
来源数据库: Springer Nature Journal
DOI: 10.1007/s11356-016-6168-5
关键词: Benzo(a)pyreneCarassius auratusEstrogenMixture toxicityKetoconazoleCYP1ACYP19Vtg
英文摘要: Abstract(#br)The aquatic environment is challenged with complex mixtures of chemicals that may interact biochemically with each other in non-target aquatic organisms through a combination of actions, resulting in unpredictable mixture toxicity. This study focuses on the interactive effects of chemicals, including benzo(a)pyrene (BaP) and ketoconazole (KCZ), on 17β-estradiol (E2)-induced estrogenic responses in male goldfish ( Carassius auratus ). The possible interactions between BaP or KCZ and E2 were investigated on the expression of cytochromeP4501A (CYP1A, biotransformation enzyme) and on its corresponding catalytic activity 7-ethoxyresorufin-O-deethylase (EROD activity), as well as on the expression of CYP19 (steroidogenic enzyme) and E2 bioaccumulation in liver. Exposure to E2...
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影响因子:2.618 (2012)

  • estrogenic 动情的
  • auratus 金黄色
  • goldfish 金鱼
  • pyrene 
  • ketoconazole 酮康唑
  • estradiol 雌二醇
  • induced 感应的
  • benzo 苯并