Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling
作者: Kenichi YoshikawaChie KuriharaHirotaka FuruhashiTakeshi TakajoKoji MarutaYuichi YasutakeHirokazu SatoKazuyuki NarimatsuYoshikiyo OkadaMasaaki HigashiyamaChikako WatanabeShunsuke KomotoKengo TomitaShigeaki NagaoSoichiro MiuraHisao TajiriRyota Hokari
作者单位: 1Division of Gastroenterology, Department of Internal Medicine, National Defense Medical College
2Division of Gastroenterology and Hepatology, Internal Medicine, The Jikei University School of Medicine
3Department of Endoscopic and Photodynamic Medicine, National Defense Medical College
4National Defense Medical College
刊名: Journal of Gastroenterology, 2017, Vol.52 (1), pp.61-71
来源数据库: Springer Journal
DOI: 10.1007/s00535-016-1205-1
关键词: NSAID enteropathyHPA axisFecal microbiota transplantationSmall intestinal permeabilityWater avoidance stress
英文摘要: Abstract(#br) Background(#br)Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular painkillers, but they have serious side effects, not only in the upper gastrointestinal tract but also in the small intestine. It is well known that psychological stress may exacerbate various gastrointestinal diseases. The aim of this study was to determine whether psychological stress exacerbates NSAID enteropathy and to determine the possible underlying mechanisms for this.(#br) Methods(#br)Experiment 1: mice were exposed to water avoidance stress (WAS) or sham stress for 1 h per day for 8 consecutive days, and then enteropathy was induced by indomethacin. Experiment 2: cecal contents from stress (−) or (+) mice were transplanted into mice that had received antibiotics and in which NSAID enteropathy...
全文获取路径: Springer  (合作)
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影响因子:3.788 (2012)

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关键词翻译
关键词翻译
  • microbiota 微生物区系
  • intestinal 肠的
  • glucocorticoid 糖皮质激素
  • receptor 接受体
  • bowel 
  • induced 感应的
  • stress 应力
  • signaling 发信号
  • injury 损害
  • permeability 磁导率