Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE
作者: Takanori MatsuiEriko OdaYuichiro HigashimotoSho-ichi Yamagishi
作者单位: 1Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications
2Kurume University School of Medicine
刊名: Cardiovascular Diabetology, 2015, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12933-014-0162-3
关键词: AGEsRAGEGLAPAptamerOxidative stress
英文摘要: Abstract(#br) Background(#br)We have previously shown that serum levels of glyceraldehyde-derived advanced glycation end products (Gly-AGEs) are elevated under oxidative stress and/or diabetic conditions and associated with insulin resistance, endothelial dysfunction and vascular inflammation in humans. Further, Gly-AGEs not only evoke oxidative and inflammatory reactions in endothelial cells (ECs) through the interaction with a receptor for AGEs (RAGE), but also mimic vasopermeability effects of AGE-rich serum purified from diabetic patients on hemodialysis. These observations suggest that Gly-AGE-RAGE system might be a therapeutic target for vascular complications in diabetes. However, since incubation of glyceraldehyde with proteins will generate a large number of structurally distinct...
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影响因子:4.209 (2012)

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关键词翻译
关键词翻译
  • pyridinium 吡啶盐
  • interaction 相互酌
  • inflammatory 激怒的
  • thrombogenic 形成血栓的
  • derived 导生的
  • stress 应力
  • oxidative 氧化的
  • cells 麻风细胞
  • endothelial 内皮的