The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
作者: Yoonhee KimChaeyoung KimSung Min SonHyundong SongHyun Seok HongSun-ho HanInhee Mook-Jung
作者单位: 1Seoul National University College of Medicine
刊名: Molecular Neurodegeneration, 2016, Vol.11 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13024-016-0068-5
关键词: PRAKRAGEAlzheimer’s diseaseAutophagy
英文摘要: Abstract(#br) Background(#br)The receptor for advanced glycation end products (RAGE) has been found to interact with amyloid β (Aβ). Although RAGE does not have any kinase motifs in its cytosolic domain, the interaction between RAGE and Aβ triggers multiple cellular signaling involved in Alzheimer’s disease (AD). However, the mechanism of signal transduction by RAGE remains still unknown. Therefore, identifying binding proteins of RAGE may provide novel therapeutic targets for AD.(#br) Results(#br)In this study, we identified p38-regulated/activated protein kinase (PRAK) as a novel RAGE interacting molecule. To investigate the effect of Aβ on PRAK mediated RAGE signaling pathway, we treated SH-SY5Y cells with monomeric form of Aβ. We demonstrated that Aβ significantly increased the...
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影响因子:4.007 (2012)

  • pathogenesis 发病机理
  • associated 相关的
  • signaling 发信号
  • disease 
  • autophagy 自体消瘦
  • novel 长篇小说