Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer
作者: Lu ZhengDa LiYi-Ming ZhouHui YangDi ChengXiao-Xin Ma
作者单位: 1Shengjing Hospital of China Medical University
2Central Hospital of Shenyang Medical College
3Brigham and Women’s Hospital, Harvard Institutes of Medicine, Harvard Medical School
刊名: BMC Cancer, 2016, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-016-2126-3
关键词: RAGEMicrovascularProliferationEndometrial cancer
英文摘要: Abstract(#br) Background(#br)The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown.(#br) Methods(#br)RAGE expression and microvessel density were examined in 20 cases of normal endometrial tissue, 37 cases of well-differentiated endometrial cancer tissue, and 35 cases of poorly-differentiated endometrial cancer tissue. Regression analysis was used to examine the relationship between RAGE and microvessel density. The knockdown of RAGE was achieved using a small interfering RNA in HEC-1A endometrial cancer cells. A xenografted tumour model was used to evaluate RAGE-mediated microvascular formation and...
全文获取路径: PDF下载  Springer  (合作)
影响因子:3.333 (2012)

  • endometrial 子宫内膜的
  • receptor 接受体
  • advanced 先进的
  • cancer 癌症
  • formation 建造