Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects
作者: Haruhisa NakaoKenji WakaiNorimitsu IshiiYuji KobayashiKiyoaki ItoMasashi YonedaMitsuru MoriMasanori NojimaYasutoshi KimuraTakao EndoMasato MatsuyamaHiroshi IshiiMakoto UenoSawako KurumaNaoto EgawaKeitaro MatsuoSatoyo HosonoShinichi OhkawaKozue NakamuraAkiko TamakoshiMami TakahashiKazuaki ShimadaTakeshi NishiyamaShogo KikuchiYingsong Lin
作者单位: 1Aichi Medical University School of Medicine
2Nagoya University Graduate School of Medicine
3Sapporo Medical University School of Medicine
4Sapporo Medical University
5Sapporo Shirakaba-dai Hospital
6Cancer Institute Hospital
7Clinical Research Center, National Hospital Organization Shikoku Cancer Center
8Kanagawa Cancer Center Hospital
9Tokyo Metropolitan Komagome Hospital
10Tokyo Metropolitan Otsuka Hospital
11Aichi Cancer Center Research Institute
12Gifu City Women’s College
13Hokkaido University Graduate School of Medicine
14National Cancer Center Research Institute
15National Cancer Center Hospital
刊名: BMC Gastroenterology, 2016, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12876-016-0503-7
关键词: FolatePolymorphismPancreatic cancerRiskCase-control study
英文摘要: Abstract(#br) Background(#br)Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects.(#br) Methods(#br)Our case-control study involved 360 newly diagnosed pancreatic cancer cases and 400 frequency-matched, non-cancer control subjects. We genotyped four folate metabolizing gene polymorphisms, including two polymorphisms (rs1801133 and rs1801131) in the methylenetetrahydrofolate ( MTHFR ) gene, one polymorphism (rs1801394) in the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ( MTRR) gene and one polymorphism (rs1805087) in the 5-methyltetrahydrofolate-homocysteine methyltransferase ( MTR) gene. Genotyping was performed using...
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来源刊物:
影响因子:2.11 (2012)

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关键词翻译
关键词翻译
  • pancreatic 胰的
  • Japanese 日本人日语日本的
  • folate 叶酸盐
  • cancer 癌症
  • between 在中间