Partial PTEN deletion is linked to poor prognosis in breast cancer
作者: P. LebokV. KopperschmidtM. KluthC. Hube-MaggC. ÖzdenTaskin B.K. HusseinA. MittenzweiA. LebeauI. WitzelL. WölberS. MahnerF. JänickeS. GeistP. PaluchowskiC. WilkeU. HeilenkötterRonald SimonGuido SauterL. TerraccianoR. KrechA. von d. AssenV. MüllerE. Burandt
作者单位: 1University Medical Center Hamburg-Eppendorf
2Regio Clinic Pinneberg
3Regio Clinic Elmshorn
4Clinical Centre Itzehoe
5Basel University Clinics
6Clinical Centre Osnabrück
7Breast Centre Osnabrück
刊名: BMC Cancer, 2015, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-015-1770-3
关键词: Breast cancerPTENFISHPrognosis
英文摘要: Abstract(#br) Background(#br)Deletions of chromosome 10q23, including the PTEN (phosphatase and tensin homolog) locus, are known to occur in breast cancer, but systematic analyses of its clinical relevance are lacking.(#br) Methods(#br)We thus analyzed a tissue microarray (TMA) with 2,197 breast cancers by fluorescence in-situ hybridization (FISH) using a PTEN -specific probe.(#br) Results(#br) PTEN deletions were detected in 19 % of no special type, 9 % of lobular, 4 % of tubular cancers and 46 % in carcinomas with medullary features. 98.7 % of deletions were heterozygous and only 1.3 % were homozygous. PTEN deletion was significantly linked to advanced tumor stage ( p = 0.0054), high-grade ( p < 0.0001), high tumor cell proliferation (Ki67 Labeling Index; p < 0.0001), and shortened...
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影响因子:3.333 (2012)

  • prognosis 预报
  • breast 胸部
  • deletion 缺失
  • cancer 癌症
  • linked 连接的