HMGB1/RAGE induces IL-17 expression to exaggerate inflammation in peripheral blood cells of hepatitis B patients
作者: JooYeon JhunSeungHoon LeeHeeYeon KimYang-Mi HerJae Kyeong ByunEun-Kyung KimSoon Kyu LeeMi-La ChoJong Young Choi
作者单位: 1The Catholic University of Korea
刊名: Journal of Translational Medicine, 2015, Vol.13 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12967-015-0663-1
关键词: HMGB1RAGEIL-17InflammationHepatitis B virus
英文摘要: Abstract(#br) Background(#br)Hepatitis B (HB) is an infectious disease with unfavorable consequence for patients and involved in chronic inflammation of liver. The present study aimed to investigate whether High-mobility group protein B (HMGB)1/receptor for advanced glycation end products (RAGE) aggravates inflammation enhancing the expression of interleukin (IL)-17.(#br) Methods(#br)Mild and severe HB liver tissue and peripheral blood samples were obtained intra-operatively. Histological analysis of the livers was performed by immunohistochemistry. IL-1β and IL-6 of liver tissue were detected by confocal microscopy staining. Relative mRNA expression was measured by real-time PCR and protein levels were measured by enzyme-linked immunosorbent assay.(#br) Results(#br)HMGB1, RAGE and IL-17...
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影响因子:3.459 (2012)

  • exaggerate 夸张
  • hepatitis 肝炎
  • inflammation 炎症
  • expression 表示
  • peripheral 周边的
  • cells 麻风细胞
  • blood 血液