PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4<sup>+</sup> T cell function
作者: Mohamed A GhonimKusma PyakurelSalome V IbbaAmir A Al-KhamiJeffrey WangPaulo RodriguezHamada F RadyAli H El-BahrawyMatthew R LammiMoselhy S MansyKamel Al-GhareebAlistair RamsayAugusto OchoaAmarjit S NauraA Hamid Boulares
作者单位: 1Louisiana State University Health Sciences Center
2Al-Azhar University
3Tanta University
4Louisiana State University
5Panjab University
刊名: Journal of Translational Medicine, 2015, Vol.13 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12967-015-0583-0
关键词: PARP inhibitionOlaparib (AZD2281)Allergen-induced eosinophiliaAdoptive transferTh2 cytokinesAllergen-specific IgE
英文摘要: Abstract(#br) Background(#br)An important portion of asthmatics do not respond to current therapies. Thus, the need for new therapeutic drugs is urgent. We have demonstrated a critical role for PARP in experimental asthma. Olaparib, a PARP inhibitor, was recently introduced in clinical trials against cancer. The objective of the present study was to examine the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in human asthma in animal models of the disease.(#br) Methods(#br)We used ovalbumin (OVA)-based mouse models of asthma and primary CD4+ T cells. C57BL/6J WT or PARP-1−/− mice were subjected to OVA sensitization followed by a single or multiple challenges to aerosolized OVA or left...
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影响因子:3.459 (2012)

  • asthma 哮喘
  • sup 吃晚饭
  • manifestation 特枕示
  • knockout 出模器
  • inhibition 抑制
  • modulating 调制的
  • function 函数
  • blocks 块状体