Clinical Significance of EphB4 and EphB6 Expression in Human Malignant and Benign Thyroid Lesions
作者: Constantinos GiaginisParaskevi AlexandrouElpida PoulakiIoanna DelladetsimaConstantinos TroungosEfstratios PatsourisStamatios Theocharis
作者单位: 1Medical School, National and Kapodistrian University of Athens
2University of the Aegean
3University of Athens
刊名: Pathology & Oncology Research, 2016, Vol.22 (2), pp.269-275
来源数据库: Springer Nature Journal
DOI: 10.1007/s12253-014-9879-2
关键词: Ephrin receptorsThyroid malignancyClinicopathological parametersImmunohistochemistryPapillary carcinomaHyperplastic nodule
英文摘要: Abstract(#br)Ephrin receptors (Ephs) are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, angiogenesis and metastasis. The present study aimed to evaluate the clinical significance of EphB4 and EphB6 protein expression in human malignant and benign thyroid lesions. EphB4 and EphB6 protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 127 patients with benign ( n = 71) and malignant ( n = 56) thyroid lesions. Enhanced EphB4 and EphB6 expression was more frequently observed in malignant compared to benign thyroid lesions ( p = 0.0508 and p = 0.0006, respectively). EphB4 and EphB6 expression also provided a distinct discrimination between papillary carcinoma and hyperplastic...
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影响因子:1.555 (2012)