New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells
作者: Sonoko AtsumiChisato NosakaHayamitsu AdachiTomoyuki KimuraYoshihiko KobayashiHisashi TakadaTakumi WatanabeShun-ichi OhbaHiroyuki InoueManabu KawadaMasakatsu ShibasakiMasabumi Shibuya
作者单位: 1Institute of Microbial Chemistry
2Jobu University
刊名: BMC Cancer, 2016, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-016-2521-9
关键词: ErtredinEGFRvIIISphere3DAnchorage-independentOxidative phosphorylationGlycolysisApoptosis
英文摘要: Abstract(#br) Background(#br) EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is likely confined to various types of cancer, particularly glioblastomas. Although an anti-EGFRvIII vaccine is of great interest, low-molecular-weight substances are needed to obtain better therapeutic efficacy. Thus, the purpose of this study is to identify low molecular weight substances that can suppress EGFRvIII-dependent transformation.(#br) Methods(#br)We constructed a new throughput screening system and searched for substances that decreased cell survival of NIH3T3/EGFRvIII spheres under 3-dimensional (3D)-culture conditions, but retained normal...
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影响因子:3.333 (2012)

  • glycolysis 糖解
  • formation 建造
  • regulate 控制
  • vitro 体外
  • growth 生长
  • oxidative 氧化的
  • chemicals 化学药品
  • derivatives 派生物
  • cells 麻风细胞
  • sphere