Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes
作者: Xiucui LuoJing PanLeilei WangPeirong WangMeijiao ZhangMeilin LiuZiqing DongQian MengXuguang TaoXinliang ZhaoJulia ZhongWeina JuYang GuEdmund C JenkinsW Ted BrownQingxi ShiNanbert Zhong
作者单位: 1Lianyungang Maternal and Children’s Hospital
2Chinese Alliance of Translational Medicine for Maternal and Children’s Health
3Peking University Center of Medical Genetics
4Hunter College High School
5New York State Institute for Basic Research in Developmental Disabilities
6Children’s Hospital of Shanghai Affiliated to Shanghai Jiaotong University
7March of Dimes Global Network of Maternal and Infant Health, March of Dimes Foundation
刊名: BMC Pregnancy and Childbirth, 2015, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12884-015-0460-0
关键词: Preterm birth (PTB)Preterm premature rupture of membrane (PPROM)Long non-coding RNA (lncRNA)mRNAPathogenic mechanism
英文摘要: Abstract(#br) Background(#br)Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human placentas derived from PPROM, PTB, premature rupture of the membranes (PROM), and full-term birth (FTB), and determined the major biological pathways involved in PPROM.(#br) Methods(#br)Here, we further investigated the relationship of lncRNAs, which are differentially expressed in spontaneous PTB (sPTB) and PPROM placentas and are found to overlap a coding locus, with the differential expression of transcribed mRNAs at the same locus. Ten lncRNAs (five up-regulated and five down-regulated) and the lncRNA-associated 10 mRNAs (six up- and four...
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影响因子:2.516 (2012)

  • inflammation 炎症
  • ubiquitin 泛激素
  • rupture 破裂
  • infection 感染
  • premature 早熟的
  • regulation 
  • system