Population structure, epidemiology and antibiotic resistance patterns of Streptococcus pneumoniae serotype 5: prior to PCV-13 vaccine introduction in Eastern Gambia
作者: Eta E. AshuSheikh JarjuMichel DioneGrant MackenzieUsman N. IkumapayiAhmed ManjangRomuladus AzuineMartin Antonio
作者单位: 1McMaster University
2Medical Research Council Unit
3King Fahad Medical City
4Global Health and Education Projects
刊名: BMC Infectious Diseases, 2016, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12879-016-1370-0
关键词: S. pneumoniaeSerotype 5ST 3404Population StructureThe GambiaPCV-13
英文摘要: Abstract(#br) Background(#br) Streptococcus pneumoniae serotype 5 is among the most common serotypes causing invasive pneumococcal disease (IPD) in The Gambia. We anticipate that introduction of the 13-valent pneumococcal conjugate vaccine (PCV-13) into routine vaccination in The Gambia will reduce serotype 5 IPD. However, the emergence of new clones that have altered their genetic repertoire through capsular switching or genetic recombination after vaccination with PCV-13 poses a threat to this public health effort. In order to monitor for potential genetic changes post-PCV-13 vaccination, we established the baseline population structure, epidemiology, and antibiotic resistance patterns of serotype 5 before the introduction of PCV-13.(#br) Methods(#br)Fifty-five invasive S. pneumoniae...
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影响因子:3.025 (2012)

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关键词翻译
关键词翻译
  • serotype 血清型
  • antibiotic 抗生素
  • vaccine 菌苗
  • epidemiology 列病学
  • introduction 导言
  • PCV Probability Control Voltage
  • Eastern 东方牌手表
  • resistance 抵抗
  • prior 预[优]先
  • structure 构造