TNF-α and INF-γ primed canine stem cell-derived extracellular vesicles alleviate experimental murine colitis
作者: Ju-Hyun AnQiang LiDong-Ha BhangWoo-Jin SongHwa-Young Youn
作者单位: 1Labolatory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine and Research institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, 08826, Seoul, Gwanak-gu, Republic of Korea
2Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 16419, Suwon-si, Gyeonggi-do, Republic of Korea
刊名: Scientific Reports, 2020, Vol.10 (1), pp.508-512
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-020-58909-4
原始语种摘要: Abstract(#br)The inflammatory bowel diseases (IBD) are characterized by relapsing inflammation and immune activation diseases of the gastrointestinal tract. Extracellular vesicles, which elicit similar biological activity to the stem cell themselves, have been used experimentally to treat dextran sulfate sodium (DSS)-induced colitis in murine models though immunosuppressive potential. In this study, we investigated whether the Extracellular vesicles (EVs) obtained by stimulating inflammatory cytokine on canine adipose mesenchymal stem cells (cASC) improved anti-inflammatory and/or immunosuppressive potential of EVs, and/or their ability to alleviate inflammation in colitis. We also explored the correlation between immune cells and the inflammatory repressive effect of primed EVs....
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)