Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo
作者: Anna RichterSina SenderAnnemarie LenzRico SchwarzBurkhard HinzGudrun KnuebelAnett SekoraHugo Murua EscobarChristian JunghanssCatrin Roolf
作者单位: 1Department of Medicine, Clinic III – Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, Ernst-Heydemann-Strasse 6, 18057, Rostock, Germany
2Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, 18057, Rostock, Germany
刊名: BMC Cancer, 2020, Vol.20 (Pt 16), pp.18-2847
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-020-6650-9
关键词: B-ALLApoptosisCK2CX-4945BCL6BACH2CDC42AKTPharmakokinetic
英文摘要: Abstract(#br)Background(#br)Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945. While reduced proliferation of tumor entities including B-ALL after CX-4945 incubation has been shown in vitro and in vivo, the detailed way of action is unknown. Here, we investigated the influence on the PI3K/AKT and apoptosis cascades in vivo and in vitro for further clarification. Methods(#br)A B-ALL xenograft model in NSG mice was used to perform in vivo longitudinal bioluminescence imaging during six day CX-4945 treatment. CX-4945 serum levels were determined at various time points. Flow cytometry of...
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影响因子:3.333 (2012)