Associations of lymphotoxin-a ( LTA ) rs909253 A/G gene polymorphism, plasma level and risk of ankylosing spondylitis in a Chinese Han population
作者: Aiping ZhuZhicheng YangHui ZhangRuiping Liu
作者单位: 1Department of Orthopaedics, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, 213003, Changzhou, China
2Department of Orthopaedics, The Jintan Hospital Affiliated to Jiangsu University, 213200, Changzhou, China
刊名: Scientific Reports, 2020, Vol.10 (1), pp.1379-90
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-020-57927-6
原始语种摘要: Abstract(#br)Lymphotoxin-a (LTA) may be associated with the pathogenesis of inflammatory diseases. To assess the association of the LTA rs909253 A/G polymorphism with plasma level and risk of ankylosing spondylitis (AS) in a Chinese Han population. Genotyping and LTA plasma were tested by mass spectroscopy and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that the average plasma level of LTA in AS was significantly lower than in the controls ( P = 0.000). Our results also indicated that LTA rs909253 A/G was associated with a decreased risk of AS (G vs. A: P = 0.014). Significant differences were also found between the rs909253 A/G genotype and down-regulated plasma level in AS patients, compared with controls. After stratification analysis, a decreased risk...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)