Domain-mediated interactions for protein subfamily identification
作者: Heetak LeeInhae KimSeong Kyu HanDonghyo KimJungho KongSanguk Kim
作者单位: 1Department of Life Sciences, Pohang University of Science and Technology, 790-784, Pohang, Korea
刊名: Scientific Reports, 2020, Vol.10 (7569), pp.309-38
来源数据库: Springer Nature Journal
DOI: 10.1038/s41598-019-57187-z
英文摘要: Abstract(#br)Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a protein family into subfamilies because the diversified functions of a single domain often depend on interacting partners of domains. Here we systematically identified DMI subfamilies, in which proteins share domains with DMI partners, as well as with various functional and physical interaction networks in individual species. In humans, DMI subfamily members are associated with similar diseases, including cancers, and are frequently co-associated with the same diseases. DMI information relates to the functional and evolutionary...
全文获取路径: Springer Nature  (合作)
影响因子:2.927 (2012)