Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients
作者: Vahinipriya ManoharanEric Hamilton KarunanayakeKamani Hemamala TennekoonSumadee De SilvaAhamed Ilyas Ahamed ImthikabKanishka De SilvaPreethika AngunawelaSameera VishwakulaJohn Lunec
作者单位: 1Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 3, Sri Lanka
2National Cancer Institute, Maharagama, Sri Lanka
3Department of Pathology, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 8, Sri Lanka
4Department of Statistics, Faculty of Science, University of Colombo, Colombo 3, Sri Lanka
5Northern Institute for Cancer Research, Newcastle University, Paul O’Gorman Building, Framlington Place, NE2 4AD, Newcastle upon Tyne, UK
刊名: BMC Cancer, 2020, Vol.20 (9), pp.2007-2017
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-020-6573-5
关键词: Breast cancerColorectal cancerSri LankaTP53Genetic variationImmunohistochemistry
原始语种摘要: Abstract(#br)Background(#br)Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its somatic mutations are reported in approximately 27% of BC and 43% of CRC cases. Analysis of TP53 gene variants not only provides clues for the aetiology of the tumour formation, but also has an impact on treatment efficacy. The current study was conducted to investigate the pattern of TP53 variants in patients with BC and CRC from Sri Lanka. Methods(#br)30 patients with BC, 21 patients with CRC and an equal number of healthy controls were screened for mutational status of TP53 by polymerase chain reaction (PCR) followed by direct sequencing. In addition, a...
全文获取路径: Springer Nature  (合作)
影响因子:3.333 (2012)