Temporal and anatomical distribution of <sup>18</sup>F-flutemetamol uptake in canine brain using positron emission tomography
作者: Taesik YunWonguk LeeJi-Houn KangMhan-Pyo YangByeong-Teck Kang
作者单位: 1Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University, 28644, Cheongju, Chungbuk, South Korea
2Department of Nuclear Medicine, Chungbuk National University Hospital, 28644, Cheongju, Chungbuk, South Korea
刊名: BMC Veterinary Research, 2020, Vol.16 (2), pp.203-212
来源数据库: Springer Nature Journal
DOI: 10.1186/s12917-020-2240-y
关键词: AmyloidCognitive dysfunction syndromeDog18F-flutemetamolPositron emission tomography
英文摘要: Abstract(#br)Background(#br)Positron emission tomography (PET) is increasingly being used as an imaging modality for clinical and research applications in veterinary medicine. Amyloid PET has become a useful tool for diagnosing Alzheimer’s disease (AD) in humans, by accurately identifying amyloid-beta (Aβ) plaques. Cognitive dysfunction syndrome in dogs shows cognitive and pathophysiologic characteristics similar to AD. Therefore, we assessed the physiologic characteristics of uptake of 18F-flutemetamol, an Aβ protein-binding PET tracer in clinical development, in normal dog brains, for distinguishing an abnormal state. Static and dynamic PET images of six adult healthy dogs were acquired after 18F-flutemetamol was administered intravenously at approximately 3.083...
全文获取路径: Springer Nature  (合作)
影响因子:1.861 (2012)