Detectable HIV-1 in semen in individuals with very low blood viral loads
作者: Samuel Mundia KariukiPhilippe SelhorstJennifer NormanKaren CohenKevin RebeCarolyn WilliamsonJeffrey R. Dorfman
作者单位: 1Division of Immunology, Department of Pathology, University of Cape Town, Anzio Rd, Observatory, 7925, Cape Town, South Africa
2International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa
3Department of Biological Sciences, School of Science, University of Eldoret, Eldoret, Kenya
4Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa
5Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
6Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
7Anova Health Institute, Cape Town, South Africa
8Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa
9Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
10National Health Laboratory Service, Johannesburg, South Africa
11Division of Virology, Faculty of Medicine and Health Sci
刊名: Virology Journal, 2020, Vol.17 (10), pp.971-975
来源数据库: Springer Nature Journal
DOI: 10.1186/s12985-020-01300-6
关键词: HIV-1SemenBloodViral load
原始语种摘要: Abstract(#br)Background(#br)Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 reservoir in the male genital tract. However, the status of this reservoir in men living with HIV-1 who are not under treatment is underexplored and has implications for understanding the origins and evolution of the reservoir. Finding(#br)Forty-three HIV-1 positive, antiretroviral therapy naïve study participants attending a men’s health clinic were studied. Semen viral loads and blood viral loads were generally correlated, with semen viral loads generally detected in individuals with blood viral loads > 10,000 cp/ml. However, we found 1...
全文获取路径: Springer Nature  (合作)
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影响因子:2.092 (2012)

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