Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation
成纤维细胞源性CXCL12通过促进肿瘤细胞内浸润促进乳腺癌转移
作者: Dinesh K. AhirwarMohd W. NasserMadhu M. OusephMohamad ElbazMaria C. CuitiñoRaleigh D. KladneySanjay VarikutiKirti KaulAbhay R. SatoskarBhuvaneswari RamaswamyXiaoli ZhangMichael C. OstrowskiGustavo LeoneRamesh K. Ganju
作者单位: 10000 0001 2285 7943, grid.261331.4, Department of Pathology, Ohio State University, 43210, Columbus, OH, USA
20000 0001 2285 7943, grid.261331.4, Department of Cancer Biology and Genetics, Ohio State University, 43210, Columbus, OH, USA
30000 0001 2285 7943, grid.261331.4, Comprehensive Cancer Center, Ohio State University, 43210, Columbus, OH, USA
40000 0001 2285 7943, grid.261331.4, Department of Internal Medicine, Ohio State University, 43210, Columbus, OH, USA
50000 0001 2285 7943, grid.261331.4, Center for Biostatistics, Ohio State University, 43210, Columbus, OH, USA
刊名: Oncogene, 2018, Vol.37 (32), pp.4428-4442
来源数据库: Springer Nature Journal
DOI: 10.1038/s41388-018-0263-7
英文摘要: Abstract(#br)The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along with various mammary tumor models to evaluate CXCL12 function in the breast cancer metastasis. Ablation of CXCL12 in stromal fibroblasts of mice significantly delayed the time to tumor onset and inhibited distant metastasis in different mouse models. Elucidation of mechanisms using in vitro and in vivo model systems revealed that CXCL12 enhances tumor cell intravasation by increasing vascular permeability and expansion of a leaky tumor vasculature. Furthermore, our studies revealed CXCL12 enhances permeability by...
全文获取路径: Springer Nature  (合作)
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影响因子:7.357 (2012)

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