Potential biomarkers of ductal carcinoma in situ progression
作者: Raquel Spinassé DettogniElaine SturAna Carolina LausRené Aloísio da Costa VieiraMárcia Maria Chiquitelli MarquesIara Viana Vidigal SantanaJosé Zago PulidoLaura Fregonassi RibeiroNarelle de Jesus ParmanhaniLidiane Pignaton AgostiniRaquel Silva dos ReisEldamária de Vargas Wolfgramm dos SantosLyvia Neves Rebello AlvesFernanda Mariano GarciaJéssica Aflávio SantosDiego do Prado VentorimRui Manuel ReisIúri Drumond Louro
作者单位: 1Department of Biological Sciences-Human and Molecular Genetics Nucleus, Federal University of Espirito Santo, Vitoria, Espirito Santo, Brazil
2Molecular Oncology Research Center-Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil
3Department of Mastology and Breast Reconstruction-Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil
4Barretos School of Health Sciences-FACISB, Barretos, Sao Paulo, Brazil
5Department of Pathology-Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil
6Evangelical Hospital of Cachoeiro de Itapemirim, Cachoeiro de Itapemirim, Espirito Santo, Brazil
7Oncology Clinical Research Center, Cachoeiro de Itapemirim, Espirito Santo, Brazil
8Life and Health Sciences Research Institute (ICVS)-Health Sciences School, University of Minho, Braga, Portugal
9ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal
刊名: BMC Cancer, 2020, Vol.20 (5), pp.1111-1118
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-020-6608-y
关键词: Ductal carcinoma in situTumor progressionFGF2GAS1SFRP1
英文摘要: Abstract(#br)Background(#br)Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for more adequate patient treatment. We aimed to identify potential biomarkers that can predict invasiveness risk. Methods(#br)In this epithelial cell-based study archival formalin-fixed paraffin-embedded blocks from six patients diagnosed with invasive lesions (pure invasive ductal carcinoma), six with in-situ lesions (pure ductal carcinoma in situ ) , six with synchronous lesions (invasive ductal carcinoma with an in-situ component) and three non-neoplastic breast epithelium tissues were analyzed by gene expression profiling of 770 genes, using the nCounter®...
全文获取路径: Springer Nature  (合作)
影响因子:3.333 (2012)