Genome-wide analysis of MicroRNA-messenger RNA interactome in ex-vivo gill filaments, Anguilla japonica
鳗鲡离体鳃丝MicroRNA信使RNA相互作用组的全基因组分析
作者: Hoi Man NgJeff Cheuk Hin HoWenyan NongJerome Ho Lam HuiKeng Po LaiChris Kong Chu Wong
作者单位: 1Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong Baptist University, Kowloon Tong, HKSAR, Hong Kong
2School of Life Sciences, Simon F.S. Li Marine Science Laboratory, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, HKSAR, Hong Kong
3Guanxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Huan Cheng North 2nd Road 109, 541004, Guilin, People’s Republic of China
刊名: BMC Genomics, 2020, Vol.21 (1), pp.R704-R713
来源数据库: Springer Nature Journal
DOI: 10.1186/s12864-020-6630-0
关键词: Fish gill osmoregulationHyperosmotic stressJapanese eelTranscriptomeMicroRNA inhibitors
英文摘要: Abstract(#br)Background(#br)Gills of euryhaline fishes possess great physiological and structural plasticity to adapt to large changes in external osmolality and to participate in ion uptake/excretion, which is essential for the re-establishment of fluid and electrolyte homeostasis. The osmoregulatory plasticity of gills provides an excellent model to study the role of microRNAs (miRs) in adaptive osmotic responses. The present study is to characterize an ex-vivo gill filament culture and using omics approach, to decipher the interaction between tonicity-responsive miRs and gene targets, in orchestrating the osmotic stress-induced responses. Results(#br)Ex-vivo gill filament culture was exposed to Leibovitz’s L-15 medium (300 mOsmol l− 1) or the medium with an adjusted...
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影响因子:4.397 (2012)

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