Comparing three induction chemotherapy regimens for patients with locoregionally advanced nasopharyngeal carcinoma based on TNM stage and plasma Epstein–Barr virus DNA level
基于TNM分期和血浆Epstein-Barr病毒DNA水平的局部晚期鼻咽癌三种诱导化疗方案的比较
作者: Sai-Lan LiuXue-Song SunHao-Jun XieQiu-Yan ChenHuan-Xin LinHu LiangYu-Jing LiangXiao-Yun LiJin-Jie YanChao LinZhen-Chong YangShan-Shan GuoLi-Ting LiuQing-Nan TangYu-Yun DuLin-Quan TangLing GuoHai-Qiang Mai
作者单位: 1Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, 651 Dongfeng Road East, 510060, Guangzhou, People’s Republic of China
2Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, People’s Republic of China
3Department of Radiation Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, People’s Republic of China
刊名: BMC Cancer, 2020, Vol.20 (1), pp.517-526
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-020-6555-7
关键词: Nasopharyngeal carcinomaInduction chemotherapyPrognosisPlasma Epstein–Barr virus
英文摘要: Abstract(#br)Background(#br)We compared the efficacy and toxicity of three IC regimens (TPF: taxanes, cisplatin, and 5-fluorouracil; TP: taxanes and cisplatin; and PF: cisplatin and 5-fluorouracil) followed by CCRT in locoregionally advanced NPC. Methods(#br)The retrospective study involved 1354 patients with newly diagnosed stage III-IVA NPC treated with IC and CCRT. The median follow-up time in our cohort was 50 months. Based on EBV DNA level, all the patients with stage IV were divided into low- (pre-EBV DNA < 1500 copies) and high-risk group (pre-EBV DNA ≥ 1500 copies). Progression free survival (PFS), overall survival (OS), locoregional relapse free survival (LRFS), distant metastasis free survival (DMFS) and grade 3–4 toxicities were compared among different IC regimens. The...
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影响因子:3.333 (2012)

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