A circuit-based mechanism underlying familiarity signaling and the preference for novelty
作者: Susanna MolasRubing Zhao-SheaLiwang LiuSteven R DeGrootPaul D GardnerAndrew R Tapper
作者单位: 1Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA
2Graduate Program in Neuroscience, University of Massachusetts Medical School, Worcester, Massachusetts, USA
刊名: Nature Neuroscience, 2017, Vol.20 (9), pp.1260-1268
来源数据库: Springer Nature Journal
DOI: 10.1038/nn.4607
英文摘要: The mechanistic basis of how novel stimuli become familiar with repeated exposures has remained elusive. Molas et al . demonstrate that familiarity activates the interpeduncular nucleus, thereby reducing motivation to explore. Familiarity signaling in the interpeduncular nucleus is bidirectionally modulated by habenula and ventral tegmental area afferents to control novelty preference.(#br)Abstract(#br)Novelty preference (NP) is an evolutionarily conserved, essential survival mechanism often dysregulated in neuropsychiatric disorders. NP is mediated by a motivational dopamine signal that increases in response to novel stimuli, thereby driving exploration. However, the mechanism by which once-novel stimuli transition to familiar stimuli is unknown. Here we describe a neuroanatomical...
全文获取路径: Springer Nature  (合作)
影响因子:15.251 (2012)