In vivo monitoring of dynamic interaction between neutrophil and human umbilical cord blood-derived mesenchymal stem cell in mouse liver during sepsis
脓毒症小鼠肝中性粒细胞与人脐血间充质干细胞动态相互作用的体内监测
作者: Sung Yong AhnYong-Sun MaengYu Rim KimYoung Ho ChoeHan Sung HwangYoung-Min Hyun
作者单位: 1Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea
2Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Republic of Korea
3Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
4BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
5Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (1), pp.165-228
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-020-1559-4
关键词: Two-photon intravital imagingSepsisHuman umbilical cord blood-mesenchymal stem cellsNeutrophilsHepatic stellate cells
英文摘要: Abstract(#br)Background(#br)Sepsis is a global inflammatory disease that causes death. It has been reported that mesenchymal stem cell (MSC) treatment can attenuate inflammatory and septic symptoms. In this study, we investigated how interactions between neutrophils and human umbilical cord blood (hUCB)-MSCs in the liver of septic mice are involved in mitigating sepsis that is mediated by MSCs. Accordingly, we aimed to determine whether hUCB-MSC application could be an appropriate treatment for sepsis. Methods(#br)To induce septic condition, lipopolysaccharide (LPS) was intraperitoneally (i.p.) injected into mice 24 h after the intravenous (i.v.) injection of saline or hUCB-MSCs. To determine the effect of hUCB-MSCs on the immune response during sepsis, histologic analysis, immunoassays,...
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影响因子:3.652 (2012)

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