Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy
作者: Khawaja Husnain HaiderBeatrice Aramini
作者单位: 1Sulaiman Alrajhi University, Al-Qaseem, Kingdom of Saudi Arabia
2Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
3Department of Basic Sciences, Sulaiman Alrajhi University, PO Box 777, 51941, Al Bukairiyah, Kingdom of Saudi Arabia
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (3), pp.457-475
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-019-1548-7
关键词: Bone marrowExosomesMesenchymalMicrovesiclesMSCsMyocardialParacrine
英文摘要: Abstract(#br)Bone marrow-derived mesenchymal stem cells (MSCs) have successfully progressed to phase III clinical trials successive to an intensive in vitro and pre-clinical assessment in experimental animal models of ischemic myocardial injury. With scanty evidence regarding their cardiogenic differentiation in the recipient patients’ hearts post-engraftment, paracrine secretion of bioactive molecules is being accepted as the most probable underlying mechanism to interpret the beneficial effects of cell therapy. Secretion of small non-coding microRNA (miR) constitutes an integral part of the paracrine activity of stem cells, and there is emerging interest in miRs’ delivery to the heart as part of cell-free therapy to exploit their integral role in various cellular processes. MSCs also...
全文获取路径: Springer Nature  (合作)
影响因子:3.652 (2012)