Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis
作者: Mi LiXin JinHao LiGang WuShanshan WangCaihong YangSisi Deng
作者单位: 1Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China
2Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China
3Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China
刊名: BMC Cancer, 2020, Vol.20 (3), pp.7-30
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-020-6542-z
关键词: OsteosarcomaMetastasisPrognosisProtein-protein interaction networkDifferentially expressed genes
原始语种摘要: Abstract(#br)Background(#br)Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with a poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma metastasis are extremely complicated. Methods(#br)A public data series (GSE21257) was used to identify differentially expressed genes (DEGs) in osteosarcoma patients that did, or did not, develop metastases. Functional enrichment analysis, a protein-protein interaction network, and survival analysis of DEGs were performed. DEGs with a prognostic value were considered as candidate genes and their functional predictions, different expression in normal and malignant tissues, and immune infiltration were analyzed. Results(#br)The DEGs were mainly enriched in the immune response. Three candidate genes...
全文获取路径: Springer Nature  (合作)
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影响因子:3.333 (2012)

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