Breast cancer-associated metastasis is significantly increased in a model of autoimmune arthritis
作者: Lopamudra Das RoyLatha B PathangeyTeresa L TinderJorge L SchettiniHelen E GruberPinku Mukherjee
作者单位: 1Department of Immunology, Mayo Clinic School of Medicine, 13400 E. Shea Blvd., 85259, Scottsdale, Arizona, USA
2Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd., 28223, Charlotte, NC, USA
3Department of Orthopedic Surgery, Carolinas Medical Center, 1543 Garden Terrace, 28232, Charlotte, NC, USA
刊名: Breast Cancer Research, 2009, Vol.11 (2 Suppl 7), pp.118-137
来源数据库: Springer Nature Journal
DOI: 10.1186/bcr2345
关键词: CelecoxibMacrophage Colony Stimulate FactorCellular InfiltrationMetastatic Breast Cancer CellArthritic Mouse
英文摘要: Abstract(#br)Introduction(#br)Sites of chronic inflammation are often associated with the establishment and growth of various malignancies including breast cancer. A common inflammatory condition in humans is autoimmune arthritis (AA) that causes inflammation and deformity of the joints. Other systemic effects associated with arthritis include increased cellular infiltration and inflammation of the lungs. Several studies have reported statistically significant risk ratios between AA and breast cancer. Despite this knowledge, available for a decade, it has never been questioned if the site of chronic inflammation linked to AA creates a milieu that attracts tumor cells to home and grow in the inflamed bones and lungs which are frequent sites of breast cancer metastasis. Methods(#br)To...
全文获取路径: Springer Nature  (合作)
影响因子:5.872 (2012)