hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum -infected mice
hUCMSC细胞外囊泡下调日本血吸虫感染小鼠肝星状细胞活化及减轻肝损伤
作者: Liyang DongYanan PuXiaojun ChenXin QiLina ZhangLei XuWei LiYongbin MaSha ZhouJifeng ZhuYalin LiXuefeng WangChuan Su
作者单位: 1State Key Lab of Reproductive Medicine, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Center for Global Health, Nanjing Medical University, 211166, Nanjing, Jiangsu, People’s Republic of China
2Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, 212000, Zhenjiang, Jiangsu, People’s Republic of China
3Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, 212000, Zhenjiang, Jiangsu, People’s Republic of China
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (492), pp.2431-135
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-019-1539-8
关键词: Human umbilical cord mesenchymal stem cellsExtracellular vesiclesSchistosomiasisLiver injury
英文摘要: Abstract(#br)Background(#br)Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous vesicles released by almost all cell types, and EVs produced by MSCs (MSC-EVs) exert therapeutic effects in several disease models. However, the potential of MSC-EVs in schistosomiasis treatment remains unclear. Methods(#br)Using survival analysis, HE and Masson’s trichrome staining, immunohistochemical, western blot analysis, real-time PCR, and EdU proliferation, we investigated the effects of human umbilical cord MSC-derived EVs (hUCMSC-EVs) on the survival and liver injury in the S. japonicum -infected mice and explored the underlying mechanism. Results(#br)Here, we...
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影响因子:3.652 (2012)

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