Discovery of inflammatory bowel disease-associated miRNAs using a novel bipartite clustering approach
作者: Md. Altaf-Ul-AminMohammad Bozlul KarimPingzhao HuNaoaki ONOShigehiko Kanaya
作者单位: 1Nara Institute of Science and Technology, Ikoma 630-0192, Japan
2University of Manitoba, Winnipeg, Canada
刊名: BMC Medical Genomics, 2020, Vol.13 (5), pp.4653-62
来源数据库: Springer Nature Journal
DOI: 10.1186/s12920-020-0660-y
关键词: IBDBiClusOMRM (miRNA regulatory module)MTI (miRNA target interaction)
原始语种摘要: Abstract(#br)Background(#br)Multidimensional data mining from an integrated environment of different data sources is frequently performed in computational system biology. The molecular mechanism from the analysis of a complex network of gene-miRNA can aid to diagnosis and treatment of associated diseases. Methods(#br)In this work, we mainly focus on finding inflammatory bowel disease (IBD) associated microRNAs (miRNAs) by biclustering the miRNA-target interactions aided by known IBD risk genes and their associated miRNAs collected from several sources. We rank different miRNAs by attributing to the dataset size and connectivity of IBD associated genes in the miRNA regulatory modules from biclusters. We search the association of some top-ranking miRNAs to IBD related diseases. We also...
全文获取路径: Springer Nature  (合作)
影响因子:3.466 (2012)