Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke
作者: Catriona J. CunninghamRaymond WongJack BarringtonSabrina TamburranoEmmanuel PinteauxStuart M. Allan
作者单位: 1Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, AV Hill Building, M13 9PT, Manchester, UK
刊名: Stem Cell Research & Therapy, 2020, Vol.11 (1), pp.245-255
来源数据库: Springer Nature Journal
DOI: 10.1186/s13287-020-1560-y
关键词: Cell therapyConditioned mediumMesenchymal stem cellSecretomeStroke
原始语种摘要: Abstract(#br)Background(#br)Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth factors, chemokines, cytokines and extracellular vesicles—collectively termed the secretome. In this study, we assessed for the first time the efficacy of the IL-1α-primed MSC-derived secretome on brain injury and functional recovery after cerebral ischaemia. Methods(#br)Stroke was induced in male C57BL/6 mice using the intraluminal filament model of middle cerebral artery occlusion. Conditioned medium from IL-1α-primed MSCs or vehicle was administered at the time of reperfusion or at 24 h post-stroke by subcutaneous injection. Results(#br)IL-1α-primed...
全文获取路径: Springer Nature  (合作)
影响因子:3.652 (2012)