MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip
MiR-182-5p及其靶向HOXA9在非小细胞肺癌中的应用:RT-qPCR、miRNA-seq和miRNA芯片联合应用的临床及矽肺探查
作者: Li GaoShi-bai YanJie YangJin-liang KongKe ShiFu-chao MaLin-zhen HuangJie LuoShu-ya YinRong-quan HeXiao-hua HuGang Chen
作者单位: 1Department of Pathology, the First Affiliated Hospital of Guangxi Medical University, Zhuang Autonomous Region, 530021, Nanning, Guangxi, China
2Department of Medical Oncology, the First Affiliated Hospital of Guangxi Medical University, Zhuang Autonomous Region, 530021, Nanning, Guangxi, China
3Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Zhuang Autonomous Region, 530021, Nanning, Guangxi, China
4Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Guangxi Medical University, Zhuang Autonomous Region, 530021, Nanning, Guangxi, China
5Department of Medical Oncology, the Second Affiliated Hospital of Guangxi Medical University, Zhuang Autonomous Region, 530021, Nanning, Guangxi, China
刊名: BMC Medical Genomics, 2020, Vol.13 (1), pp.252-271
来源数据库: Springer Nature Journal
DOI: 10.1186/s12920-019-0648-7
关键词: MiR-182-5pNon-small cell lung cancerRT-qPCRMiRNA-seqMiRNA-chipsHOXA9
英文摘要: Abstract(#br)Background(#br)MiR-182-5p, a cancer-related microRNA (miRNA), modulates tumorigenesis and patient outcomes in various human malignances. This study interroted the clinicopathological significance and molecular mechanisms of miR-182-5p in non-small cell lung cancer (NSCLC). Methods(#br)The clinical significance of miR-182-5p in NSCLC subtypes was determined based on an analysis of 124 samples (lung adenocarcinomas [LUADs], n = 101; lung squamous cell carcinomas [LUSCs], n = 23) obtained from NSCLC patients and paired noncancer tissues and an analysis of data obtained from public miRNA-seq database, miRNA-chip database, and the scientific literature. The NSCLC samples ( n = 124) were analyzed using the real-time quantitative polymerase chain reaction (RT-qPCR). Potential...
全文获取路径: Springer Nature  (合作)
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影响因子:3.466 (2012)

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