Morphine plasmatic concentration in a pregnant mare and its foal after long term epidural administration
长期硬膜外给药后妊娠母马及其马驹血浆吗啡浓度的变化
作者: Alessandro MirraJasmin BirrasSabina Diez BernalClaudia Spadavecchia
作者单位: 1Department of Clinical Veterinary Medicine, Anaesthesiology and Pain Therapy Section, Vetsuisse Faculty, University of Bern, Länggassstrasse 124, 3012, Bern, Switzerland
2Swiss Institute for Equine Medicine (ISME), Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, and Agroscope, Bern, Switzerland
刊名: BMC Veterinary Research, 2020, Vol.16 (6), pp.211-212
来源数据库: Springer Nature Journal
DOI: 10.1186/s12917-020-2242-9
关键词: HorseFoalPregnancyEpiduralMorphineMorphine-3-glucuronideMorphine-6-glucuronide
英文摘要: Abstract(#br)Background(#br)Epidural administration of morphine has been shown to be an effective analgesic strategy in horses; however, the possible occurrence of side effects limits its usage. In order to decrease their frequency, it is important to target the minimal effective plasma concentration and avoid overdosing. As to date species-specific pharmacokinetics data are not available for epidural morphine, the dosing regimen is usually established on the basis of clinical reports and personal experience. In certain physiological conditions, like gestation, the outcome of an empirical dosing scheme can be unpredictable. The aim of this case report is to describe the pharmacological profile of morphine and its metabolites after prolonged epidural administration in a pregnant mare and...
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影响因子:1.861 (2012)

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